APOE-Mimetic Peptides Reduce Behavioral Deficits, Plaques and Tangles in Alzheimer’s Disease Transgenics

APOE-mimetic peptides reduce behavioral deficits, plaques and tangles in Alzheimer's disease transgenics.

BACKGROUND After age, the second largest risk factor for Alzheimer's disease (AD) is apolipoprotein E (APOE) genotype, where APOE4 is associated with lower apoE protein levels, more severer brain pathology, enhanced inflammation and disease. Small peptides corresponding to the receptor-binding region of apoE mimic the anti-inflammatory activity of the apoE holoprotein. These apoE mimetics great...

Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease.

The distribution and density of neurofibrillary tangles and amyloid plaques was studied in a unique series of cases whose premortem cognitive status had been assessed with the Clinical Dementia Rating (CDR), including 39 nondemented cases (CDR = 0; age, 51-88 years), 15 very mildly demented cases (CDR = 0.5), and 8 severely demented (CDR = 3) cases. The initial formation of tangles and plaques ...

Plaques and tangles and the pathogenesis of Alzheimer's disease.

Since the earliest descriptions, senile plaques (SP) and neurofibrillary tangles (NFT) have been regarded as the pathological hallmarks of Alzheimer's disease (AD). Consequently, studies of the morphology, distribution, and molecular composition of SP and NFT have played an important role in developing theories as to the pathogenesis of AD; the most important being the 'Amyloid Cascade Hypothes...

The Alzheimer's disease sphinx: a riddle with plaques and tangles

U 'NLIKE other degenerative diseases of the nervous system, such as schizophrenia and Huntington's disease, Alzheimer's disease (AD) t leaves behind in the brain two clues that have provided a starting point for unraveling the pathogenesis of this illness. One clue is the senile plaque, which consists principally of extracellular fibrillar aggregates in a dense plaque core or as a diffuse infil...

Late-Onset Alzheimer’s Disease: Plaques, Tangles, and Genomics